Sample volumes in Chromatography are becoming smaller and smaller and thus safe handling of these micro volumes is more and more important. While in the past a lot of Micro-Vials were used that required an adapter to run in the autosampler nowadays people prefer those that have a safe standing position and that they can easily be put in the instrument as well as on the lab bench or in a vial rack. Further important safety aspects with Micro-Vials are risk-free injection of the needle, safe handling during filling as well as excellent sealing of the sample container. Vials with integrated Micro-Inserts – whether Glass-in-Glass or Glass-in-Plastic (TopSerts) – fulfill all these requirements. The firm integration of the Micro-Insert in the vial is not only work saving for the enduser, but also safer during filling, as a larger and handier sample container is in hands than that when using just a separate Micro-Insert. Also centering of the Micro-Insert for safe injection of the needle is guaranteed right by the design. The glass Micro-Insert of the TopSerts lies firmly in the cone of the TPX Vials and its edges slightly exceed the rims of the vial, so that the septum seals them tightly. The Glass-in-Plastic Micro-Vials are more robust and economic than the Glass-in-Glass versions. The crystal clear TPX offers good transparency and chemical resistance. TopSerts are available with 9mm Screw Neck or with 11mm Snap Ring/Crimp Neck. They can also be supplied with silanized Micro-Inserts. The Glass-in-Glass Micro-Vials can be obtained as well with 9mm Screw Neck or with 11mm Crimp Neck in clear or amber glass.